IQ-1
产品编号: DC9952
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应用领域
IQ 1 有很多作用，例如降低Wnt刺激的磷酸化，保持小鼠ESCs的多功能性，阻止PP2A/Nkd的相互作用等等。
| Cas No.: |
331001-62-8 |
| 名称: |
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| 别名: |
IQ 1; IQ1 |
| SMILES: |
CC(C1=CC=C(/N=N/C(C(N)=O)=C2NC(C)(C)CC3=CC=CC=C3/2)C=C1)=O |
| 分子式: |
C21H22N4O2 |
| 分子量: |
362.42 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vivo: |
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| In Vitro: |
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| References: |
IQ-1 has many functions such as decreasing Wnt-stimulated phosphorylation, maintaining the pluripotency of murine ESCs, preventing PP2A/Nkd interaction and so on.
1、IQ-1 maintains the pluripotency of murine ESCs in long-term culture in a Wnt-dependent manner.
2、IQ-1 decreased Wnt-stimulated phosphorylation of p300 at Ser-89.
3、 IQ-1 binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.
4、The binding of IQ-1 to PR72/130 leads to decreased phosphorylation of the coactivator protein p300 at Ser-89.
5、IQ-1 thereby diminishes the β-catenin/p300 interaction and prevents β-catenin coactivator switching from CBP to p300. |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_2903_DC9952_331001-62-8 |
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COA
| LOT NO. |
DOWNLOAD |
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询盘
