| Cas No.: | 329689-23-8 |
| 名称: | |
| 别名: | |
| SMILES: | S=C1NC(C2=CC(O)=CC=C2)C(C(OCC)=O)=C(C)N1 |
| 分子式: | C14H16N2O3S |
| 分子量: | 292.4 |
| 纯度: | |
| 保存条件: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | |
| In Vivo: | |
| In Vitro: | |
| References: | Monastrol is a reversible, cell-permeable inhibitor of the motor protein Eg5 (kinesin family protein 11, Kif11), blocking basal ATPase activity in vitro (IC50 = 6.1 µM) and inducing the formation of monoastral spindles in cell-based assays (IC50 = 51.3 μM).. It arrests cells in mitosis without targeting tubulin and, as a result, does not interfere with microtubule dependent processes. Monastrol induces activation of the spindle assembly checkpoint and the resulting mitotic arrest can lead to cell death in certain tumor cell lines. |
| Kinase Assay: | |
| Cell Assay: | |
| Animal Administration: | |
| References: |
MSDS
COA
| LOT NO. | DOWNLOAD |
|
|
|
| 2018-0101 |
|
