PRT4165（NSC-600157）
产品编号: DC9269
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应用领域
PRT4165 是一种有效的 PRC1 介导的 H2A 泛素化的抑制剂。
| Cas No.: |
31083-55-3 |
| 名称: |
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| 别名: |
PRT 4165; PRT-4165; NSC600157; NSC-600157; NSC 600157 |
| SMILES: |
C1=CC=C2C(=C1)C(=O)C(=CC3=CN=CC=C3)C2=O |
| 分子式: |
C15H9NO2 |
| 分子量: |
235.24 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vivo: |
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| In Vitro: |
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| References: |
PRT4165 is a potent inhibitor of PRC1 (Polycomb-repressive complex 1)-mediated H2A ubiquitylation.
in vitro: PRT4165 is a novel chromatin-remodeling compound and provide a new tool for the inhibition of ubiquitylation signaling at DNA double-strand breaks.PRT4165 inhibits histone H2A E3 ubiquitin ligase activity of RING1. PRT4165 Inhibits the E3 Ubiquitin Ligase Activity of PRC1. PRT4165 efficiently inhibits H2A ubiquitylation at lysine 119 (uH2AK119) and that this inhibition is dependent on both the concentration of PRT4165 and the incubation time with PRT4165. Treatment of cells for 60 min with 50 μm PRT4165 results in a dramatic reduction in total ubiquitylated histone H2A. PRT4165 inhibits the accumulation of all detectable ubiquitin at sites of DNA double-strand breaks (DSBs), the retention of several DNA damage response proteins in foci that form around DSBs, and the repair of the DSBs.
in vivo: PRT4165 inhibits the PRC1 E3 monoubiquitin ligase activity toward γ-H2AX. |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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