IMR-1
产品编号: DC9756
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应用领域
IMR-1 是一类新的 Notch 抑制剂， IC50 为 26 μM。IMR-1 阻止 Maml1 募集到染色质上的 Notch 三元复合体 (NTC)，抑制 Notch 靶基因转录并显着抑制患者衍生的肿瘤异种移植模型中的肿瘤生长。
| Cas No.: |
310456-65-6 |
| 名称: |
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| 别名: |
eFT 508,eFT-508 |
| SMILES: |
C(/C=C1\SC(=S)NC\1=O)1=CC(OC)=C(OCC(=O)OCC)C=C1 |
| 分子式: |
C15H15NO5S2 |
| 分子量: |
353.04 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
IMR-1 disruptS the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex on chromatin, thereby attenuating Notch target gene transcription. Furthermore, IMR-1 inhibited the growth of Notch-dependent cell lines and significantly abrogated the growth of patient-derived tumor xenografts. |
| Kinase Assay: |
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| Animal Administration: |
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