LMP744

产品编号: DC20275 Featured
LMP744
结构式
308246-57-3
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中国地区超过5000个高品质化合物库存
应用领域
LMP744 hydrochloride (MJ-III65 hydrochloride) 是一种 DNA 嵌和剂,是 拓扑异构酶 1 (Top1) 抑制剂,具有抗肿瘤活性。
Cas No.: 308246-57-3
名称: 6-(3-((2-hydroxyethyl)amino)propyl)-2,3-dimethoxy-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione
别名: LMP744; LMP-744; LMP 744; Mj-III-65; NSC-706744
SMILES: O=C1N(CCCNCCO)C2=C(C(C3=C2C=C(OCO4)C4=C3)=O)C5=C1C=C(OC)C(OC)=C5
分子式: C24H24N2O7
分子量: 452.1584
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: LMP744, also known as Mj-III-65 and NSC-706744, is a DNA intercalator and topoisomerase inhibitor with antitumor activity. LMP744 produces persistent topoisomerase I cleavage complexes and overcome multidrug resistance. Consistent with Top1 poisoning, protein-linked DNA breaks were detected in cells treated with LMP744 at nanomolar concentrations. Studies in human cells in culture found LMP744 to be cytotoxic. Furthermore, limited cross-resistance was observed in camptothecin-resistant cell lines. LMP744 also exhibits antitumor activity in mouse tumor xenografts.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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