GRA Ex-25
产品编号: DC9299
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应用领域
GRA Ex-25 是一种 glucagon 受体的抑制剂，抑制大鼠和人的 glucagon 受体，IC50 值分别为 56 和 55 nM。
| Cas No.: |
307983-31-9 |
| 名称: |
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| SMILES: |
C[C@](C1CC[C@H](N(C(NC2C=CC(OC(F)(F)F)=CC=2)=O)CC2C=CC(C(NCCC(O)=O)=O)=CC=2)CC1)(C)C |
| 分子式: |
C29H36F3N3O5 |
| 分子量: |
563.61 |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
GRA Ex-25(compound 15) is an orally active human glucagon receptor antagonist in a transgenic murine pharmacodynamic model at 10 and 30 mpk. GRA Ex-25 is orally bioavailable in several preclinical species and shows selectivity toward cardiac ion channels and other family B receptors, such as hGIP1 and hGLP. |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_2623_DC9299_307983-31-9 |
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COA
| LOT NO. |
DOWNLOAD |
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