| References: |
SANT-1 is a membrane permeable antagonist of the Shh (Sonic Hedgehog) signaling pathway by direct binding to Smo. This inhibition of Smo occurs equipotently by SANT-1 binding to both the oncogenic Smo and wild-type. When combined HDAC inhibitor SAHA, SANT-1 was able to suppress cellular proliferation and colony formation of Gemcitabine-resistant pancreatic adenocarcinoma cell lines Panc-1 and BxPC-3. For the detailed information of SANT-1, the solubility of SANT-1 in water, the solubility of SANT-1 in DMSO, the solubility of SANT-1 in PBS buffer, the animal experiment (test) of SANT-1, the cell expriment (test) of SANT-1, the in vivo, in vitro and clinical trial test of SANT-1, the EC50, IC50,and affinity,of SANT-1, For the detailed information of SANT-1, the solubility of SANT-1 in water, the solubility of SANT-1 in DMSO, the solubility of SANT-1 in PBS buffer, the animal experiment (test) of SANT-1, the cell expriment (test) of SANT-1, the in vivo, in vitro and clinical trial test of SANT-1, the EC50, IC50,and affinity,of SANT-1, Please contact DC Chemicals. |
