Sorafenib free base (BAY-43-9006)

产品编号: DC8791
Sorafenib free base (BAY-43-9006)
结构式
284461-73-0
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中国地区超过5000个高品质化合物库存
应用领域
Sorafenib(BAY 43-9006) is a potent inhibitor of Raf-1 with IC50 values of 6 nM, 22 nM and 90 nM for Raf-1, B-Raf, and VEGFR2 respectively, BAY 43-9006 suppresses both wild-type and V599E mutant BRAF activity in vitro.
Cas No.: 284461-73-0
名称:
别名: Bay 43-9006,Bay43-9006
SMILES: C(C(NC)=O)1=NC=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C=C2)=C1
分子式: C21H16ClF3N4O3
分子量: 464.83
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Sorafenib tosylate is the tosylate salt of sorafenib, a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). For the detailed information about the solubility of Sorafenib (BAY-43-9006) in water, the solubility of Sorafenib (BAY-43-9006) in DMSO, the solubility of Sorafenib (BAY-43-9006) in PBS buffer, the animal experiment(test) of Sorafenib (BAY-43-9006),the in vivo,in vitro and clinical trial test of Sorafenib (BAY-43-9006),the cell experiment(test) of Sorafenib (BAY-43-9006),the IC50, EC50 and Affinity of Sorafenib (BAY-43-9006), please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
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MSDS_3508_DC8791_284461-73-0
COA
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产品编号 产品名称 应用领域
DC8791 Sorafenib free base (BAY-43-9006) Sorafenib(BAY 43-9006) is a potent inhibitor of Raf-1 with IC50 values of 6 nM, 22 nM and 90 nM for Raf-1, B-Raf, and VEGFR2 respectively, BAY 43-9006 suppresses both wild-type and V599E mutant BRAF activity in vitro.