Alovudine

产品编号: DC10735 Featured
Alovudine
结构式
25526-93-6
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中国地区超过5000个高品质化合物库存
应用领域
3'-Fluoro-3'-deoxythymidine (Alovudine) 是 DNA 合成的标志物,其比 18F-Fluorodeoxyglucose (FDG) 更不易受炎症变化的影响,因此在胰腺癌中是更好的生物标志物。
Cas No.: 25526-93-6
名称:
别名: Alovudine, MIV-310; CL-184824; MIV310; CL184824; MIV 310; CL 184824
SMILES: OC[C@@H]1[C@@H](F)C[C@H](N2C(NC(C(C)=C2)=O)=O)O1
分子式: C10H13FN2O4
分子量: 244.09
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Alovudine is a dideoxynucleoside thymidine analogue, which when phosphorylated shows POLG inhibitory activity. Investigators from Medivir and their collaborators aimed to study the effects of alovudine in acute myeloid leukemia (AML) cells both in vitro and in vivo. The results showed that when OCI-AML2 cells were separately treated with alovudine and AraC, there was a reduction in the biogenesis of mtDNA and oxidative phosphorylation was impaired, as were cell growth and viability in alovudine-treated cells compared to AraC-treated cells. When alovudine was administered to AML mice (n = 10) (dosed at 50 mg/kg b.i.d. p.o.) for 11 days, it was shown that tumor volume was reduced in these mice compared to control mice (n = 10), as was tumor weight, showing a clear antileukemic activity. These results confirm alovudine to be a potent POLG inhibitor that impairs oxidative phosphorylation in AML, decreasing its growth both in vitro an in vivo
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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