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CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM.1 It is 50-fold selective For the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families.1 In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 µg/ml.2
For the detailed information about the solubility of TMS in water, the solubility of TMS in DMSO, the solubility of TMS in PBS buffer, the animal experiment（test） of TMS, the in vivo,in vitro and clinical trial test of TMS, the cell experiment（test） of TMS, the IC50, EC50 and Affinity of TMS , please contact DC Chemicals. |
