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Selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ~100, 17600 and 19800 nM For FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM For EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models.
For the detailed information about the solubility of PD-173074 in water, the solubility of PD-173074 in DMSO, the solubility of PD-173074 in PBS buffer, the animal experiment（test） of PD-173074,the in vivo,in vitro and clinical trial test of PD-173074,the cell experiment（test） of PD-173074,the IC50, EC50 and Affinity of PD-173074, please contact DC Chemicals. |
