| References: |
KNK437 dose-dependently inhibits the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in COLO 320DM (human colon carcinoma) cells. KNK437 and quercetin inhibits thermotolerance in a dose-dependent manner in PC-3 cells. KNK437 decreases heat-induced accumulation of Hsp70 mRNA and protein in PC-3 and LNCaP cells.KNK437 (200 mg/kg, i.p.) shows no antitumor effects and does not increase the thermosensitivity of nontolerant tumors. The same dose of KNK437 enhances the antitumor effects of fractionated heat treatment in a synergistic manner.[ For the detailed information of KNK437, the solubility of KNK437 in water, the solubility of KNK437 in DMSO, the solubility of KNK437 in PBS buffer, the animal experiment (test) of KNK437, the cell expriment (test) of KNK437, the in vivo, in vitro and clinical trial test of KNK437, the EC50, IC50,and affinity,of KNK437, For the detailed information of KNK437, the solubility of KNK437 in water, the solubility of KNK437 in DMSO, the solubility of KNK437 in PBS buffer, the animal experiment (test) of KNK437, the cell expriment (test) of KNK437, the in vivo, in vitro and clinical trial test of KNK437, the EC50, IC50,and affinity,of KNK437, Please contact DC Chemicals. |
