BX-471（ZK 811752）
产品编号: DC7675
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应用领域
BX471 (ZK-811752) 是以一种口服有效的，选择性，非多肽的 CCR1 拮抗剂，Ki 值为 1 nM，对其选择性是对 CCR2，CCR5 和 CXCR4 的 250 倍。
| Cas No.: |
217645-70-0 |
| 名称: |
(2R)-1-[[2-[(Aminocarbonyl)amino]-4-chlorophenoxy]acetyl]-4-[(4-fluorophenyl)methyl]-2-methylpiperazine |
| 别名: |
ZK 811752，ZK811752，ZK-811752，BX-471; BX 471,BX-471 |
| SMILES: |
C[C@@H]1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F |
| 分子式: |
C21H24ClFN4O3 |
| 分子量: |
434.89 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vivo: |
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| In Vitro: |
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| References: |
BX471 is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM For human CCR1); exhibits 250-fold selectivity For CCR1 over CCR2, CCR5 and CXCR4.
IC50 value: 1 nM(Ki)
Target: CCR1
BX471 inhibits MIP-α/CCL3-induced intracellular Ca2+ mobilization. |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
