YKL-06-061
产品编号: DC10778
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应用领域
YKL-06-061 是有效的、选择性的盐诱导激酶 (SIK) 的二代抑制剂，其对 SIK1/2/3 的IC50 值为6.56 nM/1.77 nM/20.5 nM。
| Cas No.: |
2172617-15-9 |
| 名称: |
1-Cyclobutyl-3-(2,6-dimethylphenyl)-7-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one |
| 别名: |
YKL-06-061; YKL06-061; YKL 06-061; YKL-06061; YKL06061; YKL 06061 |
| SMILES: |
O=C1N(C2CCC2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4OC)=NC=C3CN1C6=C(C)C=CC=C6C |
| 分子式: |
C30H37N7O2 |
| 分子量: |
527.3 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
YKL-06-061 is a potent and selective SIK (salt-inducible kinase) inhibitor. Salt-inducible kinases (SIKs) are related to the metabolic regulator AMP-activated protein kinase (AMPK). Salt-inducible kinase induces cytoplasmic histone deacetylase 4 to promote vascular calcification. Pharmacologic inhibition of SIK sends HDAC4 to the nucleus and inhibits the calcification process in VSMCs, aortic rings, and in vivo In the cytoplasm, HDAC4 binds and its activity depends on the adaptor protein ENIGMA (Pdlim7) to promote vascular calcification. |
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| Cell Assay: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
