| References: |
Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively. Purvalanol A reversibly arrests synchronized cells in the G1 and G2 phase of the cell cycle, inhibiting both cell proliferation and cell death.At 10 μM, purvalanol A potently suppresses the anchorage-independent growth of c-Src-transformed cells as well as HT29 and SW48 human colon cancer cells. For the detailed information of Purvalanol A(NG 60), the solubility of Purvalanol A(NG 60) in water, the solubility of Purvalanol A(NG 60) in DMSO, the solubility of Purvalanol A(NG 60) in PBS buffer, the animal experiment (test) of Purvalanol A(NG 60), the cell expriment (test) of Purvalanol A(NG 60), the in vivo, in vitro and clinical trial test of Purvalanol A(NG 60), the EC50, IC50,and affinity,of Purvalanol A(NG 60), For the detailed information of Purvalanol A(NG 60), the solubility of Purvalanol A(NG 60) in water, the solubility of Purvalanol A(NG 60) in DMSO, the solubility of Purvalanol A(NG 60) in PBS buffer, the animal experiment (test) of Purvalanol A(NG 60), the cell expriment (test) of Purvalanol A(NG 60), the in vivo, in vitro and clinical trial test of Purvalanol A(NG 60), the EC50, IC50,and affinity,of Purvalanol A(NG 60), Please contact DC Chemicals. |
