PXS-5153A

产品编号: DC12601 Featured
PXS-5153A
结构式
2125956-82-1
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中国地区超过5000个高品质化合物库存
应用领域
PXS-5153A 是一种有效的、选择性的、具有口服活性和快速起效的赖氨酰氧化酶 2/3 (LOXL2/LOXL3) 的双抑制剂,对几乎所有哺乳动物LOXL2的IC50 均< 40 nM,对人类LOXL3 的IC50 为63 nM。PXS-5153A 可减少交联,改善纤维化。
Cas No.: 2125956-82-1
名称: (Z)-3-(1-(4-amino-2-fluorobut-2-en-1-yl)-2-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-N,N-dimethylbenzenesulfonamide dihydrochloride
别名: PXS5153A;PXS 5153A
SMILES: C(S(N(C)C)(=O)=O)1=CC=CC(C2C3=NC=CC=C3N(C/C(/F)=C/CN)C=2C)=C1.[H]Cl.[H]Cl
分子式: C20H25Cl2FN4O2S
分子量: 475.404
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: PXS-5153A (PXS5153A) is a potent, selective, fast-acting, dual LOXL2/LOXL3 inhibitor with IC50 of <40 nM against all mammalian species LOXL2, inhibits human LOXL3 with IC50 of 63 nM; displays >40-fold selectivity for LOXL2 over both LOX and LOXL1 and >700
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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