| Cas No.: | 2088939-99-3 |
| 名称: | 2-[bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]-Ethanone dihydrochloride |
| 别名: | LYN-1604,LYN 1604,LYN1604 |
| SMILES: | C1=C(COC(C2=CC=C(Cl)C=C2Cl)CN2CCN(C(=O)CN(CC(C)C)CC(C)C)CC2)C=CC2C=CC=CC1=2.Cl.Cl |
| 分子式: | C33H45Cl4N3O2 |
| 分子量: | 657.54 |
| 纯度: | |
| 保存条件: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | |
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| In Vitro: | |
| References: | LYN-1604 is a ULK1 agonist. Three amino acid residues (LYS50, LEU53, and TYR89) are key to the activation site of LYN-1604 and ULK1 by site-directed mutagenesis and biochemical assays. LYN-1604 induces cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. LYN-1604 is bound to wild-type ULK1 with a binding affinity in the nanomole range (KD = 291.4 nM), but the ULK1Y89A mutant protein causes a sharp decrease in binding affinity with lower response and Kd than wild-type ULK1, ULK1K50A and ULK1L53A mutants[1].LYN-1604 could significantly inhibit the growth of xenograft MDA-MB-231 cells. LYN-1604 can directly activate ULK1, the initiator of autophagy, thereby inducing cell death to inhibit the growth of TNBC in vitro and in vivo[1]. |
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| References: |
MSDS
| TITLE | DOWNLOAD |
| MSDS_462_DC10715_2088939-99-3 |
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COA
| LOT NO. | DOWNLOAD |
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