A1874

产品编号: DC12702 Featured
A1874
结构式
2064292-12-0
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中国地区超过5000个高品质化合物库存
应用领域
A1874 是一种以 nutlin 为基础的、BRD4-降解的 PROTAC,DC50 值为 32 nM (诱导细胞内的 BRD4 降解)。有效抑制多种癌细胞增殖。
Cas No.: 2064292-12-0
名称: (2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-N-(4-((1-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)carbamoyl)-2-methoxyphenyl)-4-cyano-
别名: A-1874,A 1874
SMILES: N1[C@H](CC(C)(C)C)[C@](C2=CC=C(Cl)C=C2F)(C#N)[C@H](C2=CC=CC(Cl)=C2F)[C@H]1C(NC1=CC=C(C(=O)NCCOCCOCCOCCNC(=O)C[C@H]2N=C(C3=CC=C(Cl)C=C3)C3C(C)=C(C)SC=3N3C(C)=NN=C32)C=C1OC)=O
分子式: C58H62Cl3F2N9O7S
分子量: 1173.597
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: A1874 (A-1874) is a nutlin-based and BRD4-degrading PROTAC with DC50 of 32 nM (induce BRD4 degradation in cells); A1874 is more effective in inhibiting proliferation of many cancer cell lines with wild type p53 than was a corresponding VHL-utilizing PROTAC with similar potency and efficacy to degrade BRD4; demonstrates synergistic antiproliferative effect via simultaneous degradation of BRD4 and stabilization of p53.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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