Danicopan (ACH-4471)
产品编号: DC11082
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应用领域
Danicopan (ACH-4471,) is a highly potent, orally active Factor D inhibitor with Kd of 0.54 nM.
| Cas No.: |
1903768-17-1 |
| 名称: |
(2S,4R)-1-{[3-acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol1-yl]acetyl}-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine2-carboxamide |
| 别名: |
ACH-4471;ACH4471;ACH-0144471 |
| SMILES: |
N(C(CN1C2=C(C=C(C3=CN=C(C)N=C3)C=C2)C(C(C)=O)=N1)=O)1C[C@@H](F)C[C@@H]1C(NC1=NC(Br)=CC=C1)=O |
| 分子式: |
C26H23BrFN7O3 |
| 分子量: |
580.418 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
Danicopan (ACH-4471;ACH-0144471) is a highly potent, orally active Factor D inhibitor with Kd of 0.54 nM, inhibits the proteolytic activity of purified Factor D against substrate Factor B in complex with C3b, blocking production of Bb fragment IC50 of 15 nM; significantly reduces complement-mediated hemolysis at concentrations as low as 10 nM in cells from paroxysmal nocturnal hemoglobinuria patients, decreases C3 fragment deposition on paroxysmal nocturnal hemoglobinuria erythrocytes; blocks alternative pathway activity when administered orally to cynomolgus monkeys. |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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