CDDO-3P-Imidazolide

产品编号: DC12027 Featured
CDDO-3P-Imidazolide
结构式
1883650-95-0
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中国地区超过5000个高品质化合物库存
应用领域
CDDO-3P-Im is a new analogue of CDDO-Imidazolid,showing better bioactive than CDDO-Imidazolid.
Cas No.: 1883650-95-0
名称: 1-[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4(-pyridin-3-yl)-1H-imidazole
别名:
SMILES: C1N(C(=O)[C@@]23[C@@]([C@@]4(C(=O)C=C5[C@](C)6C(CC[C@@]5([C@]4(CC2)C)C)C(C)(C)C(=O)C(C#N)=C6)[H])([H])CC(C)(C)CC3)C=C(C2=CC=CN=C2)N=1
分子式:
分子量:
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: CDDO-2P-Im suppressed inducible nitric oxide synthase (iNOS) expression in RAW264.7 macrophage-like cells and significantly elevated heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo. Most importantly, pharmacokinetic studies performed in vitro in human plasma and in vivo showed that each new analogue was more stable than CDDO-Im. CDDO-2P-Im and CDDO-3P-Im were tested for prevention in a highly relevant mouse lung cancer model, in which A/J mice develop lung carcinomas after injection of vinyl carbamate, a potent carcinogen. CDDO-2P-Im and CDDO-3P-Im were as effective as CDDO-Im for reducing the size and the severity of the lung tumors.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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