3PO

产品编号: DC10452 Featured
3PO
结构式
18550-98-6
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中国地区超过5000个高品质化合物库存
应用领域
3PO是一种新型小分子PFKFB3同工酶的抑制剂, 显着衰减几个人恶性造血细胞和腺癌细胞系的增殖 (IC50为1.4-24 μM) 。
Cas No.: 18550-98-6
名称: 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
别名: 3 PO,3-PO
SMILES: C1=CC(=CN=C1)/C=C/C(=O)C2=CC=NC=C2
分子式: C13H10N2O
分子量: 210.07
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: 3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor. 3PO reduces glycolytic flux and suppresses glucose uptake. 3PO may be useful agents in combination with other drugs that inhibit cancer cell proliferation. PFKFB3 inhibitors suppress glucose uptake, which in turn causes an increase in autophagy. The addition of selective inhibitors of autophagy to 3PO and its more potent derivatives may prove useful as rational combinations for the treatment of cancer.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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