Ciproxifan (FUB-359)

产品编号: DC2062 Featured
Ciproxifan (FUB-359)
结构式
184025-18-1
此产品仅供科研所需,我们不出售给病人
​我们将匹配市场上最好的价格给您
Email:order@dcbio.cn
免费咨询电话:4008862077
我们的合作伙伴:
  • 20
  • 19
  • 18
  • 17
  • 16
  • 15
  • 14
  • 12
  • 11
  • 10
  • 9
  • 8
  • 13
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
中国地区超过5000个高品质化合物库存
应用领域
Ciproxifan(FUB-359)是高活性的H3受体拮抗剂,IC50为9.2 nM,对其它亚型受体的亲和力较低。
Cas No.: 184025-18-1
名称: 1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl]-
别名: FUB359
SMILES: C1CC1C(=O)C2=CC=C(C=C2)OCCCC3=CN=CN3
分子式: C15H9Cl2NO2
分子量: 306.14
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Ciproxifan, Antagonists of H3-type histamine receptors exhibit cognitive-enhancing properties in various memory paradigms as well as evidence of antipsychotic activity in normal animals.Ciproxifan is an extremely potent histamine H3 inverse agonist/antagonist.Ciproxifan produces wakefulness and attentiveness in animal studies, and produced cognitive enhancing effects without prominent stimulant effects at relatively low levels of receptor occupancy, and pronounced wakefulness at higher doses.It has there Fore been proposed as a potential treatment For sleep disorders such as narcolepsy and to improve vigilance in old age, particularly in the treatment of conditions such as Alzheimer's disease.It also potentiated the effects of antipsychotic drugs, and has been suggested as an adjuvant treatment For schizophrenia. For the detailed information about the solubility of Ciproxifan (FUB-359) in water, the solubility of Ciproxifan (FUB-359) in DMSO, the solubility of Ciproxifan (FUB-359) in PBS buffer, the animal experiment(test) of Ciproxifan (FUB-359),the in vivo,in vitro and clinical trial test of Ciproxifan (FUB-359),the cell experiment(test) of Ciproxifan (FUB-359),the IC50, EC50 and Affinity of Ciproxifan (FUB-359), please contact DC Chemicals.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DCAPI1500 Bepotastine Besilate Bepotastine Beslilate (Bepreve)是组胺H1受体拮抗剂。
DC9175 Fexofenadine Hydrochloride Fexofenadine hydrochloride (MDL-16455 hydrochloride) 是一种 H1R 拮抗剂,可用于治疗季节性过敏性鼻炎和慢性特发性荨麻疹(针对年龄大于16岁的人)。
DC8773 JNJ-7777120 JNJ-7777120是一种选择性的组胺H4受体拮抗剂, Ki值为4 ±1 nM,比作用于其他组胺受体选择性高1000多倍。
DC7995 Bilastine Bilastine是组胺H1受体拮抗剂,可作用于变应性鼻结膜炎和荨麻疹。
DC2062 Ciproxifan (FUB-359) Ciproxifan(FUB-359)是高活性的H3受体拮抗剂,IC50为9.2 nM,对其它亚型受体的亲和力较低。
DC11271 S38093 HCl S 38093 is a novel brain-penetrant antagonist/inverse agonist of H3 receptors.
DC10136 VUF10460 VUF10460是非咪唑组胺H4受体激动剂; 与大鼠H4受体结合的pKi值为7.46。
DC10102 GSK189254A GSK189254A (GSK189254)是一个新颖高效有选择性的H3受体拮抗剂,对人类和大鼠H3的pKi值分别为9.59-9.90 and 8.51-9.17。