SBI-0640756(SBI-756)

产品编号: DC10511 Featured
SBI-0640756(SBI-756)
结构式
1821280-29-8
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中国地区超过5000个高品质化合物库存
应用领域
SBI-0640756 (SBI-756) 是一种溶于水的 eIF4G1 抑制剂,能够破坏 eIF4F 复合体。
Cas No.: 1821280-29-8
名称: SBI-0640756
别名:
SMILES:
分子式:
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纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: SBI-0640756(SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. SBI-756 also suppressed AKT and NF-κB signaling. 1) SBI-756 inhibited the growth of NRAS, BRAF, and NF1-mutant melanomas . 2) SBI-756 attenuates resistance to BRAFi and inhibits NRAS- and NF1-mutant melanomas. 3) SBI-756 delayed the onset and reduced the incidence of Nras/Ink4a melanomas
Kinase Assay:
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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