| Cas No.: | 1821143-80-9 |
| 名称: | |
| 别名: | DMU2139,DMU-2139,DMU 2139,CYP1B1 inhibitor,1821143-80-9 |
| SMILES: | O=C(C1=CC=C2C=C(OC)C=CC2=C1)/C=C/C3=CC=CN=C3 |
| 分子式: | C19H15NO2 |
| 分子量: | 289.33 |
| 纯度: | |
| 保存条件: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | |
| In Vivo: | |
| In Vitro: | |
| References: | DMU2139 (6j) shows 88 and 133-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2139, the EC50 is reversed back to 8.3 μM from 61 μM (seen in CYP1B1-expressing cells without any inhibitor). The EC50 value, in the presence of DMU2139, resembles the EC50 of cisplatin, 8.7μM, in cells transfected with the empty plasmid which has no CYP1B1 gene and therefore cannot express CYP1B1 protein. |
| Kinase Assay: | |
| Cell Assay: | |
| Animal Administration: | |
| References: |
MSDS
| TITLE | DOWNLOAD |
| MSDS_810_DC11474_1821143-80-9 |
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COA
| LOT NO. | DOWNLOAD |
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