| Cas No.: | 1811510-56-1 |
| 名称: | 5-(4-chlorophenyl)-3,3'-bipyridine-6,6'-diamine dihydrochloride |
| 别名: | PF 06260933,PF-06260933,PF06260933,PF6260933,PF 6260933,PF-6260933 |
| SMILES: | C1=NC(N)=C(C2=CC=C(Cl)C=C2)C=C1C1=CC=C(N)N=C1.[H]Cl.[H]Cl |
| 分子式: | C16H13ClN4.2HCl |
| 分子量: | 369.68 |
| 纯度: | |
| 保存条件: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | |
| In Vivo: | |
| In Vitro: | |
| References: | PF 06260933 is a potent and selective MAP4K4 inhibitor (IC50 value 3.7 nM for MAP4K4 a.k.a. HGK or ZC1) with suitable PK properties in mouse to be used as a tool in an in vivo model of diabetes, vascular inflammation and atherosclerosis. Robustly prevented TNF-α-mediated endothelial permeability in vitro, similar to MAP4K4 knockdown, and without alteration of plasma lipid content. |
| Kinase Assay: | |
| Cell Assay: | |
| Animal Administration: | |
| References: |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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