GS-5734(Remdesivir)
产品编号: DC11735
Featured
我们的合作伙伴:
中国地区超过5000个高品质化合物库存
应用领域
Remdesivir (GS-5734) 是一种核苷类似物，具有抗病毒活性，在 HAE 细胞中，对 SARS-CoV 和 MERS-CoV 的 EC50 值为 74 nM，在延迟脑肿瘤细胞中，对鼠肝炎病毒的 EC50 值为 30 nM。Remdesivir 有潜力用于 2019-nCoV (COVID-19) 研究。
| Cas No.: |
1809249-37-3 |
| 名称: |
2-ethylbutyl ((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[1,2-b]pyridazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate |
| 别名: |
GS 5734;GS5734;Remdesivir |
| SMILES: |
C(OCC(CC)CC)(=O)[C@@H](C)N[P@@](OC[C@H]1[C@H](O)[C@H](O)[C@](C2N3C(=CC=2)C(N)=CC=N3)(C#N)O1)(OC1=CC=CC=C1)=O |
| 分子式: |
C28H36N5O8P |
| 分子量: |
601.597 |
| 纯度: |
|
| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
|
| In Vivo: |
|
| In Vitro: |
|
| References: |
GS-5734 (Remdesivir) is a monophosphoramidate prodrug of adenosine analogue that exhibits antiviral activity against multiple variants of EBOV (EC50=70-140 nM) and other filoviruses (EC50=0.019-1.48 uM) in cell-based assays; suppresses EBOV replication and protects 100% of EBOV-infected animals against lethal disease, ameliorating clinical disease signs and pathophysiological markers. |
| Kinase Assay: |
|
| Cell Assay: |
|
| Animal Administration: |
|
| References: |
|
MSDS
COA
| LOT NO. |
DOWNLOAD |
|
|
| 2018-0101 |
|
询盘
