Centrinone
产品编号: DC10010
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应用领域
Centrinone (LCR-263) 是选择性，可逆的 PLK4 抑制剂，Ki 值为 0.16 nM。
| Cas No.: |
1798871-30-3 |
| 名称: |
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| 别名: |
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| SMILES: |
CC1=CC(=NN1)NC2=NC(=NC(=C2OC)N3CCOCC3)SC4=C(C=C(C=C4)S(=O)(=O)CC5=C(C(=CC=C5)[N+](=O)[O-])F)F |
| 分子式: |
C26H25F2N7O6S2 |
| 分子量: |
633.65 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
Centrinone is a selective and reversible inhibitor of polo-like kinase 4 (Plk4), a serine-threonine protein kinase that initiates centriole/centrosome assembly.
Centrinone has been used to reversibly remove centrosomes from human and other vertebrate cells. Treatment with Centrinone at sub-micromolar concentrations allows persistent and reversible depletion of centrioles from cultured human and mouse cells, leading to loss of centrosomes and primary cilia. |
| Kinase Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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