AX-024 HCl
产品编号: DC10545
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应用领域
AX-024 hydrochloride 是一种口服可利用的，一流的 TCR-Nck 相互作用抑制剂，可选择性地抑制 TCR 触发的 T 细胞活化，IC50 值为 1 nM。AX-024 hydrochloride 通过靶向 SH3 结构域调节细胞信号传导。AX-024 hydrochloride 具有低毒、高效、高选择性的特点。AX-024 hydrochloride 有效抑制白细胞介素-6 (IL-6)，肿瘤坏死因子-α (TNFα)，干扰素-γ (IFN-γ)，IL-10 和 IL-17A 的产生。
| Cas No.: |
1704801-24-0 |
| 名称: |
1-((4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride |
| 别名: |
AX-024,AX024,AX 024 |
| SMILES: |
N(CC1=C(C2=CC=C(F)C=C2)C2=C(OC1)C=CC(OC)=C2)1CCCC1.[H]Cl |
| 分子式: |
C21H23FNO2Cl |
| 分子量: |
375.86 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
AX-024 is the first-in-class inhibitor of T cell receptor (TCR); AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). By modulating TCR signaling, the inhibitor prevented the development of psoriasis and asthma and, furthermore, exerted a long-lasting therapeutic effect in a model of autoimmune encephalomyelitis. |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_309_DC10545_1704801-24-0 |
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COA
| LOT NO. |
DOWNLOAD |
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