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ML 792

产品编号: DC21325 Featured
ML 792
结构式
1644342-14-2
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中国地区超过5000个高品质化合物库存
应用领域
ML-792 是一种特异性的小泛素样修饰物 (SUMO) 活化酶 (SAE) 抑制剂。ML-792 有效选择性抑制 SAE/SUMO1 和 SAE/SUMO2，IC50 分别为 3 和 11 nM。ML-792 微弱抑制 NAE/NEDD8 和 UAE/ubiquitin，IC50 分别为 32 μM 和 >100 μM。
化学性质生物活性化合物的使用COA & MSDS相关产品产品说明书
Cas No.: 1644342-14-2
名称: ((1R,2S,4R)-4-((5-(1-(3-bromobenzyl)-1H-pyrazole-3-carbonyl)pyrimidin-4-yl)amino)-2-hydroxycyclopentyl)methyl sulfamate
别名: ML 792|ML792,ML-792,1644342-14-2
SMILES: O=S(OC[C@@H]1[C@@H](O)C[C@H](NC2=NC=NC=C2C(C3=NN(CC4=CC=CC(Br)=C4)C=C3)=O)C1)(N)=O
分子式: C21H23BrN6O5S
分子量: 551.416
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: ML-792 is a potent and selective SAE inhibitor with nanomolar potency in cellular assays. ML-792 selectively blocks SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation. Moreover, Induction of the MYC oncogene increased the ML-792-mediated viability effect in cancer cells, thus indicating a potential application of SAE inhibitors in treating MYC-amplified tumors. ML-792 provides rapid loss of endogenously SUMOylated proteins, thereby facilitating novel insights into SUMO biology.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
TITLE DOWNLOAD
MSDS_1085_DC21325_1644342-14-2
COA
LOT NO. DOWNLOAD
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