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Description of Perifosine: Perifosine is an orally active alkyl-phosphocholine compound with potential antineoplastic activity. Targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. Perifosine has a lower gastrointestinal toxicity profile than the related agent miltefosine. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
For the detailed information about the solubility of Perifosine (KRX-0401) in water, the solubility of Perifosine (KRX-0401) in DMSO, the solubility of Perifosine (KRX-0401) in PBS buffer, the animal experiment（test） of Perifosine (KRX-0401),the in vivo,in vitro and clinical trial test of Perifosine (KRX-0401),the cell experiment（test） of Perifosine (KRX-0401),the IC50, EC50 and Affinity of Perifosine (KRX-0401), please contact DC Chemicals. |
