JNJ-632
产品编号: DC10882
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应用领域
JNJ-632 是一种乙型肝炎病毒 (HBV) 衣壳组装调节剂 (CAM)。
| Cas No.: |
1572510-42-9 |
| 名称: |
(S)-N-(4-fluoro-3-methylphenyl)-3-(N-(tetrahydrofuran-3-yl)sulfamoyl)benzamide |
| 别名: |
JNJ-632; JNJ 632; JNJ632 |
| SMILES: |
O=C(NC1=CC=C(F)C(C)=C1)C2=CC=CC(S(=O)(N[C@@H]3COCC3)=O)=C2 |
| 分子式: |
C18H19FN2O4S |
| 分子量: |
378.1 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vivo: |
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| In Vitro: |
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| References: |
JNJ-632 is a novel and potent inhibitor of HBV replication in vitro across genotypes A-D. It induces the formation of morphologically intact viral capsids as demonstrated by size exclusion chromatography and electron microscopy studies. Antiviral profiling in PHHs revealed that CAMs prevented formation of cccDNA in a dose-dependent fashion when the compound was added together with the viral inoculum, whereas nucleos(t)ide analogues (NAs) did not. This protective effect translated into a dose-dependent reduction of intracellular HBV RNA levels as well as reduced HBe/c, and HBsAg levels in the cell culture supernatant. |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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