Carmustine

产品编号: DC8972
Carmustine
结构式
154-93-8
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中国地区超过5000个高品质化合物库存
应用领域
Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent.
Cas No.: 154-93-8
名称:
别名:
SMILES: ClCCN(N=O)C(NCCCl)=O
分子式: C5H9Cl2N3O2
分子量: 214.05
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent.Carmustine causes cross-links in DNA and RNA, leading to the inhibition of DNA synthesis, RNA production and RNA translation (protein synthesis). Carmustine also binds to and modifies (carbamoylates) glutathione reductase. This leads to cell death. Carmustine (1,3-bis (2-chloroethyl)-1-nitrosourea) is a nitrosourea alkylating agent that exerts its antitumor effect by akylating DNA and RNA. The development of carmustine wafers (Gliadel((R)) Wafer) as a method for controlled released delivery of carmustine from biodegradable polymer wafers enhances the therapeutic ratio by fully containing the drug within the confines of the brain tumor environment while minimizing systemic toxicities.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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