| Cas No.: | 1535187-91-7 |
| 名称: | N-(3-(2-amino-6-methylpyrimidin-4-ylamino)phenyl)-3-(quinolin-4-ylamino)benzamide |
| 别名: | MC-3343;MC 3343 |
| SMILES: | C(NC1=CC=CC(NC2C=C(C)N=C(N)N=2)=C1)(=O)C1=CC=CC(NC2C3C(N=CC=2)=CC=CC=3)=C1 |
| 分子式: | C27H23N7O |
| 分子量: | 461.529 |
| 纯度: | |
| 保存条件: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | |
| In Vivo: | |
| In Vitro: | |
| References: | MC3343 (MC-3343) is a novel potent, non-nucleoside DNA methyltransferase (DNMT) inhibitor with IC50 of 5.7 and 1.7 uM for DNMT1 and DNMT3a in cell-free assays, respectively; displays increased potency against DNMT1 compared with RG-108 and SGI-1027; efficiently inhibits OS cell proliferation and induces osteoblastic differentiation, induces dose- and time-dependent decreases in DNMT1, DNMT3a and DNMT3b protein levels in Saos-2 OS cells; displays synergistic effects with doxorubicin and cisplatin in vivo, reduces patient-derived xenograft OS growth and induces differentiation. |
| Kinase Assay: | |
| Cell Assay: | |
| Animal Administration: | |
| References: |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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