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GJ103

产品编号: DC10081 Featured
GJ103
结构式
1459687-89-8
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中国地区超过5000个高品质化合物库存
应用领域
GJ103 is an active analog of the read-through compound GJ072.
化学性质生物活性化合物的使用COA & MSDS相关产品产品说明书
Cas No.: 1459687-89-8
名称:
别名: GJ 103，GJ-103
SMILES: OC(CSC1=NN=C(N1C2=CC=CC(OC)=C2)C3=NC=CC=C3)=O
分子式: C16H14N4O3S
分子量: 294.5
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: GJ103 sodium salt is an active analog of the read-through compound GJ072. In Vitro: Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations. GJ072 is a novel read-through compound (RTC). GJ072 shows activity comparable to stop codons (TGA, TAG, and TAA) PTC124 and RTC13. GJ072 induces ATM kinase on both TGA and TAG stop codons and restored ATMpSer1981 autophosphorylation and SMC1pSer966 transphosphorylation as measured by FACS. GJ072 is active in A-T cells with a homozygous TAA mutation. GJ072 is able to induce detectable full-length ATM protein in treated A-T cells. Early structure-activity relationship studies generates eight active analogs of GJ072. Some GJ072 analogs (e.g., GJ103, GJ106, GJ109, and GJ111) consistently demonstrates their activities in all three PTCs by both FCATMpSer1981 and IRIF assays. GJ071 and GJ072 and some of their analogs (such as GJ103) have similar read-through activity as RTC13 or RTC14, but are more tolerable than RTC13 and RTC14 to A-T cells. GJ103 does not show obvious cytotoxicity in A-T cells at concentration as high as 300 μM. In Vivo: GJ103 sodium salt is water soluble, making it much easier to work with in in vivo experiments.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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