Cas No.: | 1443235-95-7 |
名称: | ethyl 4-(3-methacrylamidophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate |
别名: | JAK3 inhibitor 2 |
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分子式: | C19H18N4O3 |
分子量: | 350.378 |
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保存条件: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | |
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In Vitro: | |
References: | A potent and highly selective JAK3 inhibitor with IC50 of 0.15 nM; dispalys >4,300-fold selectivity over JAK1, JAK2 and TYK2, and other kinases BMX, EGFR, ITK and BTK; blocks cytokine signaling through JAK3, but not through other JAK family enzymes; inhibits IL-7 induced pSTAT5 in CD3+, CD8+ T cells with IC50 of 280 nM; sufficiently blocks the development of inflammation in a rat model of rheumatoid arthritis, while sparing hematopoiesis. |
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