AGI-6780
产品编号: DC7174
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应用领域
AGI-6780 有效且选择性抑制肿瘤相关突变体 IDH2R140Q，IC50 为 23±1.7 nM。AGI-6780 对 IDH2WT 的作用效果微弱，IC50 为 190±8.1 nM。
| Cas No.: |
1432660-47-3 |
| 名称: |
N-cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide |
| 别名: |
AGI 6780; AGI6780 |
| SMILES: |
C(S(NC1CC1)(=O)=O)1=CC=C(C2C=CSC=2)C(NC(NC2=CC=CC(C(F)(F)F)=C2)=O)=C1 |
| 分子式: |
C21H18F3N3O3S |
| 分子量: |
481.5 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
Isocitrate dehydrogenases (IDHs) are NAD+ and NADP+-dependent enzymes in the tricarboxylic acid cycle that catalyze oxidative decarboxylation of isocitrate producing α-ketoglutarate (2-OG) and carbon dioxide. IDH1 and IDH2 are mutated in >70% of lower gra |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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询盘
