首页 > 产品 > 特色产品

ODM-203

产品编号: DC12445 Featured
ODM-203
结构式
1430723-35-5
此产品仅供科研所需，我们不出售给病人
​我们将匹配市场上最好的价格给您
Email：order@dcbio.cn
免费咨询电话：4008862077
询盘
我们的合作伙伴:
  • 20
  • 19
  • 18
  • 17
  • 16
  • 15
  • 14
  • 12
  • 11
  • 10
  • 9
  • 8
  • 13
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
中国地区超过5000个高品质化合物库存
应用领域
ODM-203 是一种有效的 FGFR 和 VEGFR 家族的抑制剂，对 FGFR1、FGFR2、FGFR3、FGFR4 的 IC50 值分别为 11 nM, 16 nM, 6 nM, 35 nM，对 VEGFR1、VEGFR2、VEGFR3 的 IC50 值分别为 26 nM, 9 nM, 5 nM。ODM-203 具有很强的抗肿瘤活性并诱导抗肿瘤免疫。
化学性质生物活性化合物的使用COA & MSDS相关产品产品说明书
Cas No.: 1430723-35-5
名称: N-(2',4'-difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-[1,1'-biphenyl]-3-yl)cyclopropanesulfonamide
别名: ODM203;ODM 203
SMILES: C(S(NC1C=C(N2C3=CC=C(C4=CN(C)N=C4)C=C3N=C2)C=C(C2=CC=C(F)C=C2F)C=1)(=O)=O)1CC1
分子式: C26H21F2N5O2S
分子量: 505.544
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: ODM-203 (ODM203) is a potent, selective, dual inhibitor of FGFR and VEGFR tyrosine kinases with approximately equal potency towards recombinant FGFR1, 2, 3 and 4, as well as VEGFR1, 2 and 3 (IC50=5-35 nM); suppresses 9/317 additional kinases by >70% at 1 uM, 9 kinases suppressed by ODM-203 - DDR1, MAP4K4, MINK1, RET, PDGFRa and SIK2 (IC50<100 nM); ODM-203 is a potent inhibitor of FGFR signaling and proliferation in several FGFR-dependent cell lines; ODM-203 inhibits VEGFR-induced tube formation (IC50 33 nM) with similar potency as it inhibits proliferation in FGFR-dependent cell lines (IC50 50-150 nM); inhibits FGFR phosphorylation and tumor growth in several FGFR-dependent xenografts.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DC26116 Poloppin Poloppin is a cell-active, small molecule inhibitor of protein-protein interaction via the Polo-box domain (PBD) of the mitotic Polo-like kinase (PLK) with IC50 of 26.9 uM (PLK1) in FP assays.
DC26114 GpTx-1 GpTx-1 is a potent, selective, 34-residue peptide antagonist of Nav1.7 sodium channel with IC50 of 10 nM, displays 20- and 1000- fold selectivity over NaV1.4 and NaV1.5..
DC26113 LSP4–2022 LSP4–2022 is a novel potent, selective, brain-penetrant mGluR4 agonist with EC50 of 0.11 uM in cell-based assays.
DC26109 MCL0129 tetrahydrochloride MCL0129 is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3.
DC26100 SR-16507 SR-16507 is a potent full agonist of ORL1 receptor (NOP receptor) and partial agonist of mu-opioid receptor with Ki of 5.22 nM and 1.07 nM, respectively.
DC26091 PF-05198007 PF-05198007 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 9 nM, no significant activity against Nav1.5 (IC50>10 uM).
DC26081 JTE-852 JTE-852 is a novel potent, selective, ATP-competitive Syk kinase inhibitor with IC50 of 1.25/1.28 nM for human/rat Syk, respectively.
DC26080 GX-674 GX-674 is a potent, selective Nav1.7 inhibitor with IC50 of 0.1 nM.
DC26078 GNE-616 GNE-616 (GNE616) is a highly potent, metabolically stable, subtype selective inhibitor of Nav1.7 with Ki of 0.79 nM (hNav1.7).
DC26071 BMS 814580 A highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM.
​ 免费咨询电话：4008862077
​ QQ：1026657369
​ 邮箱：order@dcbio.cn
我们所有的产品仅供研究所需，严禁用于人体和其他目的
站点地图|隐私政策Copyright © 2018-2020 All Rights Reserved. 技术支持:库价软件