SP2509

产品编号: DC7956
SP2509
结构式
1423715-09-6
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中国地区超过5000个高品质化合物库存
应用领域
SP2509 is a novel histone demethylase LSD1 (KDM1A) antagonist with IC50 of 13 nM; no inhibition on MAO-A and MAO-B.
Cas No.: 1423715-09-6
名称: (E)-N'-(1-(5-chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide.
别名: SP 2509,SP-2509
SMILES: O=C(N/N=C(C1=CC(Cl)=CC=C1O)C)C2=CC=CC(S(=O)(N3CCOCC3)=O)=C2
分子式: C19H20ClN3O5S
分子量: 437.9
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: SP2509 attenuated the binding of LSD1 with the corepressor CoREST, increased the permissive H3K4Me3 mark on the target gene promoters, and increased the levels of p21, p27 and CCAAT/enhancer binding protein α in cultured AML cells. In addition, SP2509 tre
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
TITLE DOWNLOAD
MSDS_3464_DC7956_1423715-09-6
COA
LOT NO. DOWNLOAD
产品编号 产品名称 应用领域
DC7956 SP2509 SP2509 is a novel histone demethylase LSD1 (KDM1A) antagonist with IC50 of 13 nM; no inhibition on MAO-A and MAO-B.
DC5204 OG-L002 OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively.