Cilofexor
产品编号: DC10868
Featured
我们的合作伙伴:
中国地区超过5000个高品质化合物库存
应用领域
Cilofexor (GS-9674) 是一种有效的，选择性的，口服活性的非甾体 FXR 激动剂，EC50 为 43 nM。Cilofexor 具有抗炎和抗纤维化作用。Cilofexor 可用于原发性硬化性胆管炎 (PSC) 和非酒精性脂肪性肝炎 (NASH) 的研究。
| Cas No.: |
1418274-28-8 |
| 名称: |
2-(3-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxyazetidin-1-yl)isonicotinic acid |
| 别名: |
GS-9674;GS9674，Cilofexor |
| SMILES: |
ClC1=CC=CC(Cl)=C1C2=NOC(C3CC3)=C2COC4=CC=C(C5(O)CN(C6=NC=CC(C(O)=O)=C6)C5)C=C4 |
| 分子式: |
C28H22Cl3N3O5 |
| 分子量: |
586.85 |
| 纯度: |
|
| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
|
| In Vivo: |
|
| In Vitro: |
|
| References: |
Cilofexor (GS-9674, GS9674, PX-104) is a novel specific, non-steroidal farnesoid X receptor (FXR) agonist that reduces liver fibrosis and ameliorates portal hypertension in rat NASH models. |
| Kinase Assay: |
|
| Cell Assay: |
|
| Animal Administration: |
|
| References: |
|
MSDS
COA
| LOT NO. |
DOWNLOAD |
|
|
| 2018-0101 |
|
询盘
