GDC-0084（RG7666）
产品编号: DC9708
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应用领域
GDC-0084 是一种能透过血脑屏障的 PI3K 和 mTOR 抑制剂，抑制 PI3Kα，PI3Kβ，PI3Kδ，PI3Kγ 和 mTOR，Ki 值分别为 2 nM，46 nM，3 nM，10 nM 和 70 nM。
| Cas No.: |
1382979-44-3 |
| 名称: |
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| 别名: |
RG7666; RG-7666; RG 7666; GDC-0084; GDC0084; GDC 0084 |
| SMILES: |
CC1(C2=NC3=C(N2CCO1)N=C(N=C3N4CCOCC4)C5=CN=C(N=C5)N)C |
| 分子式: |
C18H22N8O2 |
| 分子量: |
382.43 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| References: |
GDC-0084, also known as RG7666, is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor GDC-0084 specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in the inhibition of both cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. |
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MSDS
| TITLE |
DOWNLOAD |
| MSDS_2737_DC9708_1382979-44-3 |
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COA
| LOT NO. |
DOWNLOAD |
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询盘
