KML-29
产品编号: DC10536
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应用领域
KML29是一种有效的选择性MAGL抑制剂, 抑制人, 小鼠, 和大鼠脑蛋白酶时, IC50 分别为5.9, 15, 和 43 nM。
| Cas No.: |
1380424-42-9 |
| 名称: |
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| 别名: |
KML29,KML-29,KML 29 |
| SMILES: |
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCC(C(C2=CC=C(OCO3)C3=C2)(O)C4=CC(OCO5)=C5C=C4)CC1 |
| 分子式: |
C24H21F6NO7 |
| 分子量: |
549.4 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vitro: |
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| References: |
KML29 is an O-hexafluoroisopropyl carbamate analog of JZL 184 that potently and selectively inhibits MAGL (IC50s = 15, 43, and 5.9 nM in mouse, rat, and human brain proteomes, respectively) over FAAH (IC50s >50 μM). At 5-20 mg/kg, KML29 dose-dependently blocks mouse brain MAGL activity in vivo, without any measurable effect on FAAH activity.As a second generation MAGL inhibitor, KML29 supersedes the low-level cross reactivity that JZL 184 displays for FAAH yet still maintains comparable potency to its parent compound.. |
| Kinase Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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