SSE15206

产品编号: DC11476 Featured
SSE15206
结构式
1370046-40-4
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中国地区超过5000个高品质化合物库存
应用领域
SSE15206 是一种微管 (microtubule) 聚合抑制剂,其在 HCT116 细胞中的 GI50 值为 197 nM,能克服多重耐药性。引起细胞中纺锤体形成不完全,从而导致 G2/M 阻滞,有丝分裂异常。
Cas No.: 1370046-40-4
名称: 4,5-Dihydro-3-phenyl-5-(3,4,5-trimethoxyphenyl)-1H-pyrazole-1-carbothioamide
别名: SSE15206; SSE-15206; SSE 15206,1370046-40-4
SMILES: S=C(N1N=C(C2=CC=CC=C2)CC1C3=CC(OC)=C(OC)C(OC)=C3)N
分子式: C19H21N3O3S
分子量: 371.45
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: SSE15206 is a microtubule depolymerizing agent that overcomes multidrug resistance. SSE15206 has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents. Treatment of cells with SSE15206 causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation, a phenotype often associated with drugs that interfere with microtubule dynamics. SSE15206 inhibits microtubule polymerization both in biochemical and cellular assays by binding to colchicine site in tubulin as shown by docking and competition studies.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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