| Cas No.: | 1346623-17-3 |
| 名称: | (2R,3S)-2-(4-(cyclopentylamino)phenyl)-1-(2-fluoro-6-methylbenzoyl)-N-(4-methyl-3-(trifluoromethyl)phenyl)piperidine-3-carboxamide |
| 别名: | Avacopan; CCX168; CCX-168; CCX 168 |
| SMILES: | N(C(=O)C1=C(C)C=CC=C1F)1CCC[C@@H](C(NC2=CC=C(C)C(C(F)(F)F)=C2)=O)[C@H]1C1=CC=C(NC2CCCC2)C=C1 |
| 分子式: | C33H35F4N3O2 |
| 分子量: | 581.656 |
| 纯度: | |
| 保存条件: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | |
| In Vivo: | |
| In Vitro: | |
| References: | A potent, selective, orally availale C5aR (CD88) inhibitor with IC50 of 0.1 nM; shows no activity (IC50 >5,000 nM)for C5aR-related receptors C5L2, C3aR, ChemR23, GPR1 and FPR1; inhibits C5a-mediated chemotaxis of U937 cells with pA2 of 0.2 nM; shows activity in mouse model of ANCA-induced glomerulonephritis. |
| Kinase Assay: | |
| Cell Assay: | |
| Animal Administration: | |
| References: |
MSDS
COA
| LOT NO. | DOWNLOAD |
|
|
|
| 2018-0101 |
|
