| References: |
Tyrphostin AG490 is a JAK-2 specific inhibitor, which inhibits phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT-3], and subsequently reduce invasion and adhesion potential of malignant cells. The hematopoietic cancer c-Kit+, Jak-2+ and non hematopoietic tumors c-Kit+, HER-2+, JAK-2+ can be inhibited by the chemosensitizing agent AG490 causing programmed cell death.
For the detailed information about the solubility of AG 490 in water, the solubility of AG 490 in DMSO, the solubility of AG 490 in PBS buffer, the animal experiment（test） of AG 490,the in vivo,in vitro and clinical trial test of AG 490,the cell experiment（test） of AG 490,the IC50, EC50 and Affinity of AG 490, please contact DC Chemicals. |
