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Ricolinostat (ACY-1215)

产品编号: DC7048
Ricolinostat (ACY-1215)
结构式
1316214-52-4
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中国地区超过5000个高品质化合物库存
应用领域
Rocilinostat (ACY-1215) is a selective HDAC6 inhibitor with IC50 of 5 nM; >10-fold more selective for HDAC6 than HDAC1/2/3 (class I HDACs) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2.
化学性质生物活性化合物的使用COA & MSDS相关产品产品说明书
Cas No.: 1316214-52-4
名称: 5-Pyrimidinecarboxamide,2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-
别名: Rocilinostat; ACY1215; ACY 1215,Ricolinostat
SMILES: O=C(C1=CN=C(N(C2=CC=CC=C2)C3=CC=CC=C3)N=C1)NCCCCCCC(NO)=O
分子式: C24H27N5O3
分子量: 433.5
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: ACY-1215 is a hydroxamic acid derivative. ACY-1215 is 12-, 10-, and 11-fold less active against HDAC1, HDAC2, and HDAC3 (class I HDACs), respectively. ACY-1215 has minimal activity (IC50 > 1μM) against HDAC4, HDAC5, HDAC7, HDAC9, HDAC11, Sirtuin1, and Sir
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
产品编号 产品名称 应用领域
DCAPI1434 Romidepsin（FK-228） Romidepsin strongly inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 25 nM and 790 nM, respectively.
DC7048 Ricolinostat (ACY-1215) Rocilinostat (ACY-1215) is a selective HDAC6 inhibitor with IC50 of 5 nM; >10-fold more selective for HDAC6 than HDAC1/2/3 (class I HDACs) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2.
DC5178 Tubacin (BML-GR362) Tubacin is a selective inhibitor of HDAC6 via inhibition of the second deacetylase domain (DD2).
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