| Cas No.: | 1311136-84-1 |
| 名称: | (5R)-5-ethyl-3-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-2,4-imidazolidinedione |
| 别名: | AUT-1;AUT 1 |
| SMILES: | C(=O)1N[C@@H](CC)C(=O)N1C1=CC=C(OC2=CC=C(C)C(OC)=C2)N=C1 |
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| 保存条件: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | |
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| References: | A novel specific, cell permeant modulator of Kv3 channels with EC50 of 4.7 and 4.9 uM for Kv3.1b and Kv3.2a, respectively; displays approximately 10-fold lower potency for Kv3.3 channels, and does not interact with a wide range of ion channels, receptors, and transporters; increases hKv3.1b and hKv3.2a currents by 1049 ± 198% and 226 ± 39%, respectively, at 30 uM; rescue the fast firing capability of FS interneurons following a reduction in Kv3 channel availability, has the potential to rescue normal function and therapeutic benefit in disorders like schizophrenia or age-related cognitive decline. |
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MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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