ODM-201(Darolutamide)
产品编号: DC8700
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应用领域
Darolutamide (ODM-201;BAY-1841788) 是有效的雄激素受体 (AR) 拮抗剂, 在体内试验中的 IC50 值为26 nM。
| Cas No.: |
1297538-32-9 |
| 名称: |
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| 别名: |
BAY-1841788,ODM-021,0DM021,ODM 021 |
| SMILES: |
N1N=C(C(=O)N[C@H](CN2N=C(C3C=C(Cl)C(C#N)=CC=3)C=C2)C)C=C1C(C)O |
| 分子式: |
C19H19ClN6O2 |
| 分子量: |
398.85 |
| 纯度: |
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| 保存条件: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
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| In Vivo: |
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| In Vitro: |
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| References: |
ODM-201 is a potent and full antagonists for human AR (hAR) with IC50 values of 26 nM by transactivation assays in AR-HEK293 cells.in vitro: ODM-201 is a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies. In competitive AR binding assays, the inhibition constant (Ki) values of ODM-201 were 11 nM.
in vivo: ODM-201 inhibits tumor growth in a castration-resistant VCaP xenograft model in vivo. ODM-201 shows a significant antitumor activity with both doses, 50 mg/kg twice daily being more efficacious compared to castrated, untreated mice (p < 0.001). |
| Kinase Assay: |
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| Cell Assay: |
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| Animal Administration: |
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| References: |
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MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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