SNS-062

产品编号: DC10488 Featured
SNS-062
结构式
1270014-40-8
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中国地区超过5000个高品质化合物库存
应用领域
BTK IN-1 (SNS062 analog) 是一种有效的 BTK 抑制剂,IC50 值 <100 nM。
Cas No.: 1270014-40-8
名称: N-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)-2-((3-chlorophenyl)amino)acetamide
别名: SNS-062,SNK062,SNS 062
SMILES: O=C(CNC1=CC(Cl)=CC=C1)NC(CCC2)CN2C3=NC=NC4=C3C=CN4
分子式: C19H21ClN6O
分子量: 384.87
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: SNS-062 is a non-covalently binding inhibitor of Bruton's tyrosine kinase (BTK). This target mediates signaling through the B-cell receptor, or BCR, which is critical for adhesion, migration, proliferation and survival of normal and malignant B-lineage lymphoid cells. BTK has been well validated as a target for treatment of B-cell malignancies, with a BTK inhibitor approved for relapsed/refractory mantle cell lymphoma, relapsed/refractory chronic lymphocytic leukemia, or CLL, CLL with 17p depletion and Waldenström's macroglobulinemia. Because SNS-062 has demonstrated a distinct binding site and favorable pharmacokinetic profile in preclinical studies, SNS-062 may provide differentiated opportunities for treatment of B-cell malignancies and other blood cancers.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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