| References: |
GS967 is a novel, potent, and selective inhibitor of cardiac late sodium current(late INa); inhibits ATX-II-induced late I(Na) in ventricular myocytes and isolated hearts with IC(50) values of 0.13 and 0.21 μM, respectively.Reduction of peak I(Na) by GS967 was minimal at a holding potential of -120 mV but increased at -80 mV. GS967 did not prolong action potential duration or the QRS interval. GS967 prevented and reversed proarrhythmic effects (afterdepolarizations and torsades de pointes) of the late I(Na) enhancer ATX-II and the I(Kr) inhibitor E-4031 in isolated ventricular myocytes and hearts For the detailed information of GS967, the solubility of GS967 in water, the solubility of GS967 in DMSO, the solubility of GS967 in PBS buffer, the animal experiment (test) of GS967, the cell expriment (test) of GS967, the in vivo, in vitro and clinical trial test of GS967, the EC50, IC50,and affinity,of GS967, Please contact DC Chemicals. |
