CycLuc1(Luciferase substrate)

产品编号: DC10610 Featured
CycLuc1(Luciferase substrate)
结构式
1247879-16-8
此产品仅供科研所需,我们不出售给病人
​我们将匹配市场上最好的价格给您
Email:order@dcbio.cn
免费咨询电话:4008862077
我们的合作伙伴:
  • 20
  • 19
  • 18
  • 17
  • 16
  • 15
  • 14
  • 12
  • 11
  • 10
  • 9
  • 8
  • 13
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
中国地区超过5000个高品质化合物库存
应用领域
CycLuc1 是一种可渗透血脑屏障的荧光素酶 (luciferase) 底物。
Cas No.: 1247879-16-8
名称: 2-(6,7-Dihydro-5H-thiazolo[4,5-f]indol-2-yl)-4,5-dihydro-thiazole-4-carboxylic acid
别名: CycLuc1
SMILES: C1C2NCCC=2C=C2N=C(C3SC[C@@H](C(O)=O)N=3)SC=12
分子式: C13H11N3O2S2
分子量: 305.38
纯度:
保存条件: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description:
In Vivo:
In Vitro:
References: The synthetic firefly luciferase substrate CycLuc1 offers brighter bioluminescence and improved imaging in mouse models at lower doses than the standard D-luciferin. Binds to luciferase with higher affinity and and emits about 5.7-fold more light than aminoluciferin and 3.2-fold more light than D-luciferin. Its superior light output is maintained over a wide range (1-100 µM). Shown to readily cross the blood-brain barrier in mice and provides much improved noninvasive bioluminescence imaging (BLI) of the brain at lower dose when compared to D-luciferin. Yields about 10-fold higher bioluminescent signal than D-luciferin when Luc2 luciferase expressing 4T1 breast cancer cells are implanted into the mammary fat pads of BABL/c mice. A rapid (4-5 min), long-lasting, and steady signal peak is observed following an i.v injection CycLuc1 in mice.
Kinase Assay:
Cell Assay:
Animal Administration:
References:
MSDS
TITLE DOWNLOAD
MSDS_370_DC10610_1247879-16-8
COA
LOT NO. DOWNLOAD
产品编号 产品名称 应用领域
DC12654 PLX8394 PLX8394 是一种有效的,选择性的 BRaf 抑制剂,抑制 BRAFV600E 活性的 IC50 值约为 5 nM。
DC9743 CB1954(Tretazicar) CB1954(Tretazicar) in stock,price: 350 USD/100mg. CB1954(Tretazicar) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent.It can
DC26175 NLX-101(F-15599) NLX-101(F-15599) is a novel compound that activates serotonin 5-HT1A receptors with exceptional selectivity, having over 1000-fold higher affinity for this target over other receptors.
DC26173 YM-53601 YM-53601 is a squalene synthase inhibitor (IC50s = 79 and 90 nM in HepG2 cells and rat liver microsomes, respectively).
DC26160 Ethosalamide Etosalamide, also known as Ethosalamide, is an antipyretic and analgesics agent.
DC26155 Sulfaphenazole Sulfaphenazole is an inhibitor of CYP2C9 (Ki = 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Kis = 63 and 29 μM for CYP2C8 and CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19).
DC26151 Naloxone (hydrochloride) Naloxone is an opioid inverse agonist drug used to counter the effects of opiate overdose.
DC26139 2-(5-Chloro-1H-indol-2-yl)acetic acid 2-(5-Chloro-1H-indol-2-yl)acetic acid|CAS 720000-48-6
DC12542 GOT1 inhibitor 2c GOT1抑制剂2c是谷氨酸草酰乙酸转氨酶1(GOT1)的一流的非共价抑制剂,IC50为8.2μM。
DC12541 iGOT1-01 iGOT1-01 is a small molecule inhibitor of aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1 (GOT1)) with IC50 of 11.3 uM.